NFL DFS Cheat Sheet for PrizePicks: Week 15
The PrizePicks NFL Cheat Sheet for Week 15 is your comprehensive guide to dominating NFL DFS this Sunday. Below, you’ll find the best NFL DFS picks, game targets, and WR vs. CB matchups to help you dominate your fantasy football playoffs and maximize your NFL DFS winnings on PrizePicks.
Build your Lineups with these insights into the best opportunities on the PrizePicks NFL board this week. From must-watch games to high-upside matchups and touchdown scorer targets, we've got everything you need to cash out on PrizePicks in Week 15.
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PrizePicks NFL Cheat Sheet for NFL DFS
Find the top picks, matchups to target, and TD scorer predictions for NFL DFS Week 15 below in the PrizePicks Cheat Sheet.
- Best Games to Target
- Best OL vs. DL Matchups to Target
- Best WR vs. CB Matchups to Target
- Best TD Scorer Picks
Top Games to Target in Week 15 for DFS
Steelers vs. Eagles — 4:25 p.m. ET
A highly anticipated matchup this week is the “Battle of Pennsylvania,” as the Steelers (10-3) travel cross-state to face the Eagles (11-2). Historically, the Steelers have struggled in Philadelphia, failing to notch a victory there since the 1990s and often playing second fiddle to their in-state counterparts.
Pittsburgh’s offense, led by a surging QB Russell Wilson, has been firing on all cylinders as of late. Wilson is averaging nearly 255 passing yards per game and faces a stingy Eagles defense that ranks third in passing yards allowed.
Wilson’s passing yards projection sits at 195 yards, a benchmark he has surpassed in nine of his last 10 games. Still, the Steelers’ offensive line will face a formidable challenge against the Eagles’ stout defensive front. Running back Najee Harris, who has hit his PrizePicks rushing projection of 53 yards in 10-of-13 games, will be tested by one of the league’s top run-stopping units.
On the other side, Eagles RB Saquon Barkley has inserted himself into the MVP conversation with a phenomenal season. This week, he meets a Steelers run defense that ranks top-five in limiting rushing yards to running backs, allowing just 91 yards per game on average. Barkley has a lofty projection of 98 rushing yards, a figure he has eclipsed in 9-of-13 games (about 70%).
Meanwhile, the Steelers’ vulnerability lies in their secondary, which ranks 23rd, allowing 237 passing yards per game. With Philadelphia’s A.J. Brown recently expressed frustration over his production, this could be a breakout spot against a suspect Pittsburgh pass defense.
PrizePicks Picks: A.J. Brown more than 80.5 Receiving Yards / Saquon Barkley less than 100.5 Rush Yards
Bills vs. Lions — 4:25 p.m. ET
In another marquee showdown, the Buffalo Bills (10-3) head to Detroit to face the 12-1 Lions in a potential Game of the Year candidate. Despite their stellar record, the Lions’ secondary has been shaky, ranking 25th in passing yards allowed (243 yards per game).
Bills QB Josh Allen, averaging about 233 passing yards per contest, should find a favorable matchup — especially WR Amari Cooper against rookie CB Terrion Arnold, who ranks 102nd among 113 cornerbacks in coverage. The Lions favor man-to-man defense, which plays into the hands of Buffalo’s savvy receiving corps.
However, the Bills have their own Achilles’ heel: stopping the run. They sit near the bottom of the league in rushing yards allowed and will face the Lions’ two-headed backfield of Jahmyr Gibbs and David Montgomery.
Gibbs, averaging nearly 80 rushing yards per game, has a projection of 68.5 yards, which he’s surpassed in 70% of his appearances. Buffalo’s linebacking corps and interior run-stoppers, including DT Ed Oliver (102nd of 133 in run-stopping grade among interior defenders), face a daunting challenge against Detroit’s powerful ground game.
Both of these matchups carry significant playoff implications and should provide high-quality, late-season drama for NFL fans and bettors alike.
PrizePicks Picks: Josh Allen more than 259.5 Pass Yards / Amari Cooper more than 46.5 Receiving Yards / Jahmyr Gibbs more than 69.5 Rush Yards
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Best OL/DL Matchups to Target: Week 15
Here are the best OL vs. DL matchups to take advantage of for NFL DFS in Week 15.
Saints OL vs. Commanders DL
One of the few bright spots for the New Orleans Saints this season is their offensive line.
Center Erik McCoy stands out, ranking second among 41 centers and allowing zero sacks with just two total pressures all year. Former first-round pick Taliese Fuaga has excelled at left tackle, surrendering only seven quarterback hits and ranking 38th out of 133 tackles in run-blocking. At guard, Lucas Patrick ranks 25th among 75 NFL guards and hasn’t given up a single sack, further solidifying this unit.
Conversely, the Commanders’ defensive line has been among the league’s most disappointing. Rookie DT Jer’Zhan Newton out of Illinois has underperformed, placing 105th out of 125 interior defensive linemen. Free-agent addition Clelin Ferrell has failed to meet expectations, ranking 112th among 116 edge defenders. Even veteran Daron Payne is having a down year, ranking 54th of 125 interior linemen, a far cry from his past success.
PrizePicks Picks: Alvin Kamara more than 62.5 Rush Yards / more than 0.5 Rush+Rec TDs
Ravens DL vs. Giants OL
On the other hand, the Baltimore Ravens feature one of the NFL’s top defensive fronts.
Ravens DT Travis Jones shines, ranking seventh out of 133 interior defenders in run-stopping. Former first-round edge rusher Odafe Oweh ranks in the top 15 for both quarterback hits and sacks, coming in 35th out of 116 edge defenders overall.The Giants offensive line issues mirror the state of their quarterback position, which helps explain their two-win season. C John Michael Schmitz ranks 39th out of 40 centers in pass-blocking, allowing six sacks and 26 total quarterback pressures. Former top-10 pick Evan Neal has also struggled, ranking 70th out of 79 offensive tackles and allowing 11 quarterback hits. These protection woes have severely limited the Giants’ offensive potential.
PrizePicks Picks: Tommy DeVito less than 177.5 Pass Yards
Best WR vs. CB Matchups to Target: Week 15
Commanders WR Terry McLaurin vs. Saints CB Alontae Taylor
Commanders WR Terry McLaurin is enjoying one of his best seasons yet, thanks in part to rookie QB Jayden Daniels leading the offense. When targeted, McLaurin boasts a top-five passer rating of 141 and averages over 14 yards per reception, placing him in the top 10 in receiving yards.
He’ll be facing cornerback Alontae Taylor, who has struggled in coverage since stepping in for the departed Marshon Lattimore. Taylor ranks 112th out of 113 cornerbacks, has allowed an NFL-high 62 receptions, and surrenders a passer rating above 110 when targeted.
PrizePicks to Consider: Terry McLaurin 3.5 Receptions – More (Goblin)
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Eagles WR AJ Brown vs. Steelers CB Joey Porter Jr.
Eagles WR A.J. Brown remains one of the league’s premier wideouts, despite recent injury battles and a dip in production. He’s still posting a near-130 passer rating when targeted and averaging over 17 yards per reception, good for a top-15 ranking in receiving yards this season.
Brown will line up against former second-round pick Joey Porter Jr., who is allowing over 12 yards per reception and has given up 38 catches this season. Porter’s performance places him 98th out of 113 graded cornerbacks, which is a clear mismatch.
PrizePicks to Consider: AJ Brown 0.5 Rush+Rec TD (Demon)
Best TD Scorer Picks for Week 15
Find three more TD scorer predictions for Week 15 here.
Cardinals TE Trey McBride vs. Patriots (Demon)
Cardinals TE Trey McBride has emerged as one of the best tight ends in the NFL, hovering near the top five in categories like targets, receptions, receiving yards, and even drops. When targeted, McBride produces a passer rating above 100 and averages over 10 yards per reception. He has quickly become a favorite target in the offense.
This week, McBridge will face a struggling Patriots linebacking corps. LB Jahlani Tavai ranks 75th of 81 linebackers in coverage, while Christian Elliss ranks 58th. Adding to the challenge for New England’s defense, safety Kyle Dugger ranks 91st of 93 at his position in coverage, allowing a passer rating of around 140.
Giants WR Malik Nabers vs. Ravens (Demon)
While Baltimore’s defensive line has excelled, their secondary has lagged behind. Cornerback Brandon Stephens has been notably poor, ranking 108th out of 113 cornerbacks. He’s allowing a passer rating over 110, more than 13 yards per reception, and has yielded the fifth-most receptions (50) in the NFL.
This sets up a favorable matchup for Giants rookie WR Malik Nabers. Despite playing with a struggling quarterback all season, Nabers ranks inside the top five in both receptions and targets, averaging over 10 yards per catch and producing a near-100 passer rating when targeted — remarkable for a first-year player transitioning from the college ranks.
Lock in for Week 15 NFL DFS on PrizePicks
Week 15 is here, bringing a Sunday packed with exciting NFL matchups and division titles on the line. Use the PrizePicks NFL Cheat Sheet to sharpen your takes and build your winning Lineups for Sunday.
PrizePicks is the simplest way to play NFL daily fantasy sports all season, even through the NFL Playoffs. Visit the PrizePicks NFL board, pick at least two player projections — like yards or touchdowns — and lock in your Lineup.
Keep it dialed in on the Playbook for more PrizePicks picks and predictions for NFL DFS and fantasy football all season long.
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