NFL Divisional Round PrizePicks Cheat Sheet for NFL DFS
Only eight NFL teams remain as we head into the Divisional Round this weekend. Get ready for the four NFL Divisional Round games full of NFL DFS action in the second weekend of the 2025 NFL Playoffs.
This PrizePicks Cheat Sheet is your go-to resource for the top Divisional Round picks, projections, and matchups to cash in on NFL DFS on PrizePicks in all four games this weekend — from the Saturday games to Sunday Night Football.
Build your winning Lineups with these expert insights into the biggest opportunities on the PrizePicks NFL board this weekend, with WR vs. CB matchups, OL vs. DL mismatches, and TD scorer predictions. We’ve got everything you need to cash out on PrizePicks.
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NFL Divisional Round: NFL DFS Cheat Sheet for PrizePicks
Find the top picks, matchups to target, and TD scorer predictions for NFL DFS in Divisional Round below in the PrizePicks Cheat Sheet for this week.
- NFL Divisional Round Best Games to Target
- NFL Divisional Round OL/DL Matchups to Target
- Best WR vs. CB Matchups in Divisional Round
- Best TD Scorer Predictions for Divisional Round
Top Divisional Round Games to Target for NFL DFS
Here are the two best NFL Divisional Round games to target for your NFL DFS Lineups on PrizePicks.
Eagles vs. Rams — Sunday, 3 p.m. ET
The Eagles face a highly favorable matchup against a Rams run defense that has struggled significantly this season. While linebacker Christian Rozeboom ranks seventh out of 85 linebackers in run-stopping, he receives minimal support from the rest of the unit.
Those struggles were evident the last time the Eagles met the Rams, when Saquon Barkley ran for 255 yards and two touchdowns on 26 carries. Much of that success can be attributed to Philadelphia’s superior offensive line overwhelming the Rams’ defensive front.
On defense, the Eagles will be without one of their top linebackers, Nakobe Dean, after he went down in the Wild Card win. Despite that loss, Philadelphia is a top-10 unit against both the run and the pass, posing a formidable test for QB Matthew Stafford and the Rams’ offense.
If Los Angeles is to exploit any weakness, it likely lies over the middle of the field. TE Tyler Higbee, who returned from injury this year and racked up 60 yards in just one quarter against the Minnesota Vikings, will be a key factor in that approach. With the Eagles missing a key piece at linebacker, Higbee could be a central figure in the Rams’ game plan.
Unfortunately, the Rams came out of the Wild Card victory over the Vikings banged up, with Higbee, NT Bobby Brown III, CB Akhello Witherspoon, and OT Alaric Jackson all missing practice time on short rest after their Monday night victory. However, all are expected to play come Sunday.
PrizePicks Pick: Eagles QB Jalen Hurts 34.5 Rushing Yards – More / TE Tyler Higbee Receptions — More (not yet posted due to injury status)
Bills vs. Ravens — Sunday, 4:30 p.m. ET
The Buffalo Bills have a favorable matchup against a Baltimore secondary that ranks 31st in the NFL in passing yards allowed per game (283) and 30th in completions allowed (nearly 24 per game). This sets up Josh Allen for potentially big numbers in the air.
That said, Allen struggled in his first matchup with this Ravens defense, passing for 180 yards and rushing for 21 more. Since making massive adjustments to their defensive scheme after Week 10, the Ravens rank first in opponent expected points added (-.129, second is -.092), and first in opponent dropback EPA (-.121, second is -.040). We’ll find out what gives in this matchup.
Conversely, the Ravens will square off against a Bills defense that struggles against the run — 21st in rushing yards allowed (over 100 yards per game). This is significant because Baltimore’s offense features one of the best QB-RB rushing tandems in Lamar Jackson and Derrick Henry.
In the first matchup between these teams, the Ravens rushed for 271 yards, including 199 from Henry, in a 35-10 win in Baltimore. However, the Bills were missing two starting LBs in that matchup — Matt Milano and Terrel Bernard — who will start in this game.
In a cold-weather scenario where passing might be limited, the Ravens’ run-first approach could give them a major advantage.
PrizePicks Picks: Ravens QB Lamar Jackson 40.5 Rush Yards – More
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Best OL/DL Matchups to Target in NFL Divisional Round
Games are won in the trenches, especially in the NFL Playoffs. Here are two OL vs. DL mismatches to take advantage of for NFL DFS on PrizePicks the Divisional Round games this weekend.
Texans DL vs. Chiefs OL
Although the Chiefs’ offensive line is one of the better units in the NFL overall, both tackles have struggled. LT D.J. Humphries has very limited experience this season (fewer than 100 snaps) and is up there in age, at 31 years old. He’ll have to fend off DE Danielle Hunter, who ranks 14th out of 111 edge rushers in pass rushing, per PFF, and sits top 10 in total pressures, QB hits, sacks, and forced fumbles, boasting 12 sacks on the year.
On the right side, Chiefs tackle Jawaan Taylor is 61st out of 81 tackles, notorious for accumulating 17 penalties, allowing 7 sacks, and 37 QB pressures this season. He’ll square off against first-round pick Will Anderson Jr., who ranks 6th out of 113 defensive ends, already has 12 sacks as a rookie, and should pose a big challenge ot this defensive line.
While the Texans may not have the same success against the Chiefs as their four-sack, nine-QB hit performance versus the Chargers, the Chiefs will need to scheme quick passes to counteract a strong Texans DL that could cause problems.
PrizePicks Picks: Chiefs QB Patrick Mahomes 250.5 Pass Yards – Less
Eagles OL vs. Rams DL
Philadelphia’s offensive line is arguably the best in the NFL. LT Jordan Mailata ranks 1st out of 81 tackles, while RT Lane Johnson ranks 7th, per PFF. LG Landon Dickerson is 9th among 77 guards, and their other interior linemen, such as free-agent pickup Mekhi Becton (16th out of 77), further strengthen the unit.
They’ll face a Rams defense that has only one standout pass rusher on the edge — rookie Jared Verse, who ranks 9th out of 113 defensive ends. Beyond Verse, however, the Rams drop off considerably: Byron Young is 66th out of 118 at his position, per PFF, and Braden Fisk is 125th out of 140 interior defenders in run-stopping, which is bad news against this Saquon Barkley-led rushing attack that every NFL has struggled to stop.
In these teams’ first matchup, Barkley rushed for 255 yards on a whopping 9.8 yards per attempt with two touchdowns. He also added four catches for 47 yards.
As seen in the Wild Card Round against the Packers, the Eagles seem content to keep the ball on the ground, and they should find plenty of success against the Rams
PrizePicks Picks: Eagles RB Saquon Barkley more than 127.5 Rush+Rec Yards — More
Best WR vs. CB Matchups in NFL Divisional Round
All year, we’ve identified the best WR vs. CB matchups to target for NFL DFS on PrizePicks. We’ve only got four games to choose from this Divisional Round weekend, but here are two WRs who have the advantage in their WR vs. CB matchups.
Eagles WR A.J. Brown vs Rams CB Akello Witherspoon
Rams CB Ahkello Witherspoon has been average in coverage this season, ranking 67th out of 117 cornerbacks in the NFL in coverage, per PFF. He allows a passer rating of over 100 and just over 13 yards per reception.
The former third-round pick faces a tough assignment this week against Eagles star wideout A.J. Brown. Despite a perceived “lack of production” by his own high standards, Brown still owns a 124 passer rating when targeted, averages over 16 yards per reception, and has already surpassed 1,000 receiving yards this season.
Having recently voiced frustration over his usage, Brown may see more targets than usual, especially in a matchup where they hold a big advantage.
PrizePicks Picks: Eagles WR A.J. Brown 69.5 Receiving Yards – More
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Ravens WR Rashod Bateman vs. Bills CB Rasul Douglas
CB Rasul Douglas is one weak point the Baltimore Ravens can exploit in the Bills secondary. This season, Douglas ranks 111th out of 233 cornerbacks, via PFF, allowing a passer rating near 124, over 40 receptions, and more than 12 yards per reception.
The 2017 third-round pick will be matched up against Ravens WR Rashod Bateman, who’s enjoying a significantly better year than in seasons past. Benefiting from an injury to Zay Flowers — who looks like he may sit or be significantly limited again this week — Bateman sits in the top 10 for receiving touchdowns (with 8) and boasts a 132 passer rating when targeted, placing him among the league’s elite — on par with receivers like Terry McLaurin and A.J. Brown.
PrizePicks Picks: Rashod Bateman 42.5 Receiving Yards – More
Best TD Scorer Predictions for Divisional Round
Here are two of the top TD scorer predictions for the Divisional Round. Take their Rush+Rec TD projection on PrizePicks and cash it if they score a rushing or receiving TD.
Eagles WR DeVonta Smith vs. Rams (Demon)
Rams nickelback Quentin Lake, a 2022 sixth-round pick, has had a below average season in coverage, ranking 65th out of 97 at his position. When targeted, he allows a near-100 passer rating and over 11 yards per reception. More concerning, he’s given up 43 receptions — a bottom-10 mark in the NFL for safeties — despite playing over 1,000 snaps and recording zero interceptions.
Lining up primarily in the slot, Lake will square off against the Eagles’ slot receiver DeVonta Smith, who’s having a stellar year. Smith has topped 1,000 yards, posted a 125 passer rating when targeted, averages over 12 yards per reception, and has 8 touchdowns, ranking him inside the top 15 among wide receivers.
Commanders WR Terry McLaurin vs. Lions (Demon)
Lions rookie CB Terrion Arnold, has struggled in coverage, ranking 177th out of 223 cornerbacks, per PFF. He has allowed the 10th-most receptions (56) in the NFL, gives up a 100 passer rating, and surrenders over 13 yards per reception.
He’ll return from injury for the Divisional Round and be tasked with defending Commanders WR1 Terry McLaurin, who’s enjoying one of the best seasons of his career with rookie quarterback Jayden Daniels.
McLaurin has exceeded 1,000 receiving yards, ranks second in the league with 13 receiving touchdowns, posts the second-best passer rating when targeted (135.3), and sits inside the top 20 in both receptions and targets.
McLaurin tends to come through when the Commanders need to throw the ball. In 13 Commanders games decided by one possession or losses, McLaurin has scored 11 touchdowns. Last week, in a tight game against the Bucs, Daniels threw to his top target 10 times for 89 yards and a touchdown.
McLaurin has scored eight touchdowns in the last seven games, only missing the end zone in one game over that span.
Cash in on the NFL Divisional Round on PrizePicks
The always-anticipated NFL Divisional Round weekend is here, bringing us four must-watch games on Saturday and Sunday, packed with matchups between some of the best teams in the league. Use the PrizePicks NFL Cheat Sheet to sharpen your takes and build out your winning Lineups for the NFL Divisional Round games.
PrizePicks is the easiest way to win real money with your NFL takes all season, even through the NFL Playoffs. Visit the PrizePicks NFL board, pick at least two player projections — like receiving yards or touchdowns — and lock in your Lineup. Get paid instantly if your picks are correct.
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