Week 15 NFL DFS Picks, Predictions & Top Matchups For Main Slate
Bye weeks are over for the season. We’ve hit the key stretch of the season, as some teams make a push for a playoff spot, while others already have their sights set on the 2025 Draft.
Let’s dive into the NFL DFS slate for Week 15 by highlighting some of the top projections to target on PrizePicks for Sunday’s slate.
PrizePicks is the easiest way to get paid for your NFL takes. Just pick more or less on at least two player projections — like yards, receptions, or touchdowns — and cash out when your picks are correct.
This week’s picks are made that much easier with the Patrick Mahomes free pick; if Mahomes passes for 0.5 pass yards, you’ll cash his projection.
NFL Week 15 Picks for DFS & PrizePicks
- NFL Week 15 Injury Report + Notes
- Week 15 Pass Defense to Target
- Week 15 Run Defenses to Target
- Week 15 DFS Picks
Week 15 NFL Injury Report
Jets RB Breece Hall (Knee) Not Expected To Be Shut Down
Jets RB Breece Hall missed his first game of the season Sunday against the Dolphins. While there has been no indication that he will be sidelined for the remainder of the season, his status is uncertain for Week 15 against the Jaguars. Jets RBs Isaiah Davis and Braelon Allen split carries with Hall out last week. Allen turned 11 carries into 43 yards, while Davis had 10 carries for 40 yards and a touchdown. Allen also added four receptions for 38 yards, and Davis had three catches for 27 yards.
Steelers WR George Pickens (Hamstring) Likely Out Again
Steelers WR George Pickens did not play against the Browns last week, marking his first missed game of the season. Steelers head coach Mike Tomlin said that Pickens is likely doubtful to play in Week 15 against the Eagles.
With him sidelined against the Browns, Steelers TE Pat Freiermuth led the team with 48 receiving yards, while WRs Scotty Miller, Calvin Austin III, and Mike Williams each had four targets.
Buccaneers RB Bucky Irving Dealing With Back Injury
Leading up to Week 14, Buccaneers RB Bucky Irving was battling a hip injury. While he played, he lasted just 10 offensive snaps before departing with back tightness. His status is uncertain for a Week 15 matchup against the Chargers.
Buccaneers RB Rachaad White stepped up to produce 109 total yards and two total touchdowns last week and would likely remain in an expanded role if Irving misses more time.
Saints QB Derek Carr (Hand) is Week-To-Week
Saints QB Derek Carr fractured his left, non-throwing hand against the Giants last week. While he has not been placed on injured reserve, he is being considered as week-to-week, but could miss the rest of the season.
If he is unable to play against the Commanders on Sunday, then the Saints will have to decide between QB Jake Haener and QB Spencer Rattler as their starter. It would also likely lead to far more usage and offensive sets for Taysom Hill.
Other NFL Week 15 Injuries for DFS
- Titans QB Will Levis had a disappointing performance against the Jaguars last week, throwing for 168 yards and no touchdowns. Levis said that he aggravated his sprained AC joint during the game and did what he could to come out and play the second half. If Levis is unable to play in Week 15, Titans QB Mason Rudolph would be in line to start against the Bengals.
- Panthers rookie RB Jonathon Brooks missed the first 10 games of the season while recovering from a torn ACL. He lasted just three games before tearing it again. With him out, Panthers RB Chuba Hubbard should be busy as the season comes to a close. Last week, Hubbard ran for 92 yards and a touchdown against the Eagles.
- Giants QB Drew Lock is undergoing an MRI for an undisclosed injury, but head coach Brian Daboll said Lock will start if he is able to Sunday against the Ravens. In his two starts, Lock has no passing touchdowns, one rushing touchdown, and has thrown two interceptions. If Lock is unable to play, then Giants QB Tommy DeVito will take his place under center.
- Chargers WR Ladd McConkey was sidelined by a knee injury Sunday against the Chiefs. In his absence, Chargers WR Joshua Palmer led the team with nine targets. He turned them into six receptions for 78 yards. Chargers WR Quentin Johnston caught five of seven targets for 48 yards and a touchdown. Should McConkey be unable to return for this Sunday, both Palmer and Johnston will likely be looking at additional targets again.
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NFL Week 15 Pass Defenses to Target
Bengals Defense vs. Titans
The Bengals struggling on defense is why the team has been a disappointment. Per 4for4 Fantasy Football, the Bengals have the ninth-highest pass EPA per play allowed (0.08) in the league. They are also tied for the third-most passing touchdowns allowed (24).
This should be a great matchup to exploit, but with Levis dealing with a shoulder injury, there is a bit of a reason to pause. I might even feel better about the Titans’ wide receivers if Rudolph gets the start, because at least we know he is healthy.
PrizePicks to consider: Calvin Ridley 64.5 Receiving Yards
Panthers Defense vs. Cowboys
While the Panthers have been more competitive down the stretch, their defense is still struggling. They have the fourth-highest pass EPA per play allowed (0.11) in the league, per 4for4. They have also allowed the seventh-highest explosive pass percentage (14.52%). Finally, like the Bengals, they are tied for third-most passing touchdowns allowed (24) in the league.
Cooper Rush has passed for under 200 yards in each of the last two games, but has at least 31 pass attempts in every start, showing the Cowboys commitment to the pass.
PrizePicks to consider: Cooper Rush 211.5 Pass Yards / WR CeeDee Lamb 66.5 Receiving Yards
NFL Week 15 Run Defenses to Target
Giants Defense vs. Ravens
Despite a litany of injuries, the Giants actually held their own on defense against the Saints last week. Facing a loaded Ravens team that is well rested after their bye week is another matter.
The Giants have been particularly poor at stopping the run, recording the fifth-highest rush EPA per play allowed (0.04) in the league, per 4for4.
PrizePicks to consider: Derrick Henry 101.5 Rush Yards
Cowboys Defense vs. Panthers
The Cowboys suffered a big loss on defense last week with LB DeMarvion Overshown going down with a knee injury. He tore his ACL, MCL, and PCL, so his season is over. Overshown was huge in run-stopping for the Cowboys.
The Cowboys have already struggled to defend the run with him healthy, allowing the sixth-highest explosive rush percentage (14.05%) in the league, per 4for4. With Brooks out, Hubbard should be the bell-cow back for this Panthers offense.
In five games with at least 18 carries this year, Hubbard has gone more than this number every time.
PrizePicks to consider: Chuba Hubbard 78.5 Rush Yards
Week 15 NFL DFS Picks
Find the top NFL DFS picks for Week 15 on PrizePicks below, including the Patrick Mahomes free pick.
Patrick Mahomes Free Pick: 0.5 Passing Yards — More
PrizePicks is giving you a free pick for your Lineups this week. Lock in Patrick Mahomes 0.5 pass yards square for 99% off before his game this Sunday against the Browns.
If Mahomes throws for at least one yard, you’ll cash this projection on NFL Sunday! You can only use the free square in a Lineup once, so choose wisely.
Jets WR Davante Adams 68.5 Receiving Yards – More
Jets QB Aaron Rodgers threw for 339 yards against the Dolphins last week, marking his first game of the season with at least 300 passing yards. Jets WR Davante Adams caught nine passes for 109 yards and a touchdown in the game. He has received at least 11 targets in four of his last five games.
Adams also finished with at least 66 receiving yards four times during that span. The Jaguars have allowed the third-most yards per target to wide receivers (9.00) in the league, leaving Adams with significant upside.
Commanders RB Brian Robinson Jr. 70.5 Rush Yards – More
Commanders RB Brian Robinson Jr. will have fresh legs after the Commanders had their bye last week. In his last game, he ran 16 times for 103 yards and a touchdown against the Titans. Another 15+ carries should be coming his way this week with Austin Ekeler (concussion) on injured reserve.
That leaves Robinson in a great spot to be productive against the Saints, who have the third-highest rush EPA per play allowed (0.08) in the league, per 4for4.
Best TD Scorer Pick: Browns TE David Njoku (Demon)
Browns QB Jameis Winston has thrown eight touchdown passes over his last four games. Three of those touchdowns have gone to Browns TE David Njoku. Over the last three games, Njoku has received five targets inside the 10-yard line.
As good as the Chiefs have been on defense, they have allowed the most receptions to tight ends (86) in the league. Given their struggles to defend the position and Njoku’s usually hefty workload, he could produce his third straight game with at least one score.
Note: Demon picks add a payout boost to your lineup on PrizePicks, as they are more difficult projections to hit.
Goblin Pick: Ravens RB Derrick Henry 0.5 Rush+Rec TDs – More
Ravens RB Derrick Henry has 13 rushing touchdowns and two receiving touchdowns this season. That has helped him score at least one touchdown in all but two of his games. Given how poorly the Giants have performed against the run, Henry has an excellent opportunity to reach the end zone again here.
Note: Goblin picks reduce your payout on PrizePicks, as they are easier projections to hit.
Build Your Week 15 NFL DFS Lineup on PrizePicks
There will be no shortage of action in Week 15 with every NFL team in action. There is no better way to get in on the fun than by building an NFL DFS team on PrizePicks for the Sunday main slate.
There are no salary constraints, so just pick two or more projections for your favorite players, finalize your lineup, sit back, and enjoy the games.
Don’t forget to take advantage of the Chiefs QB Patrick Mahomes 0.5 pass yards to make your Lineup that much easier. All Mahomes needs to do is throw for one passing yard for his pick to hit!
More Fresh Picks & Insights
