NFL Week 4 Cheat Sheet for PrizePicks and DFS
It’s time to lock in for a packed Week 4 NFL DFS action on PrizePicks. Below, we’ll get into the best matchups and spots to target on the Week 4 NFL slate with the PrizePicks Cheat Sheet and find the plays that help you create your winning lineup.
With three weeks under our belts, the Week 4 NFL matchups are stacked with opportunities, with plenty of injuries to adjust for. We’ll go over the games to target, best matchups, and TD scorer picks to load up in your PrizePicks Lineup.
Don’t forget to head to the PrizePicks NFL board, lock in your picks, and build your Lineup your way to get in on the real money sports action for Week 4.
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NFL Week 4 Cheat Sheet for PrizePicks
- Week 4 Best Game to Target
- Week 4 Best OL/DL Matchups to Target
- Week 4 WR/CB Matchups to Target
- Week 4 Best Touchdown Scorer Picks
Top Game to Target in Week 4 for DFS
Rams vs. Bears — 1 p.m. ET
Last week, Bears rookie QB Caleb Williams broke out with 363 passing yards against the Colts. He’s primed for another huge game this week at home against a struggling Rams defense.
With the possible return of WR Keenan Allen, Williams will have more options in his arsenal, including the emerging rookie WR Rome Odunze, who scored last week. His primary target, WR DJ Moore, has been heavily involved in the offense, ranking fifth in the NFL with 27 targets.
Moore faces a cake matchup against Rams corner Tre’Davious White, who is still recovering from an ACL tear and has struggled this season. White has allowed completions on 8-of-12 targets, with QBs posting a near 150 passer rating when targeting him.
Additionally, White is giving up a massive 18 yards per reception, making him a vulnerable target for Moore and Williams.
Tight end Cole Kment has also seen high volume this season, ranking fifth in targets and third in receptions among tight ends.
Like Moore, he gets a favorable matchup against the Rams' linebackers, who have struggled in coverage. Christian Rozeboom ranks 40th out of 72 linebackers, while Troy Reeder ranks 31st.
Pair the final Williams free square of September with Moore or Kmet receiving yards in a soft matchup against a poor Rams defense.
PrizePicks to Consider: Caleb Williams more than 215.5 passing yards (0.5 with free square) / DJ Moore more than 56.5 receiving yards
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Best OL/DL Matchups to Target: Week 4
Saints OL vs. Falcons DL
The Saints have one of the best offensive lines in the NFL when fully healthy, but they're facing some serious setbacks. Center Eric McCoy, who anchors the offensive line, has been placed on IR, and guards Cesar Ruiz and Landon Young are both questionable, potentially leaving the Saints without three key linemen.
Their replacements haven’t performed up to expectations. Olisaemeka Udoh ranks 67th out of 74 graded tackles and struggled in his shift to guard last week. First-round pick Taliese Fuaga has also struggled, as he currently ranks 63rd out of 74 graded tackles.
This weakened unit will be tested against the Atlanta Falcons defense, led by veterans Matthew Judon, Lorenzo Carter, and Grady Jarrett, who are poised to give the Saints' patchwork line significant trouble.
PrizePicks to Consider: Derek Carr less than 222.5 pass yards
Cardinals OL vs. Commanders DL
The Arizona Cardinals' offensive line has been one of the league's best this season. Rookie Paris Johnson Jr. ranks 12th out of 74 graded tackles and has been a crucial piece protecting Kyler Murray's blindside.
This week, they face the Commanders, who are on short rest and are already one of the league’s worst defensive units.
The Commanders' defensive front hasn’t lived up to expectations, with edge rusher Dante Fowler ranking 70th out of 105 graded ends and new signing Dorance Armstrong ranking 91st out of 105. Even veteran Jonathan Allen, who leads the middle, has struggled, ranking 77th out of 129 interior defensive linemen.
The Cardinals offensive line should keep the pocket clean for Murray to cook this defense.
PrizePicks to Consider: QB Kyler Murray more than 232.5 pass yards / WR Marvin Harrison Jr. more than 66.5 receiving yards
Best WR/CB Matchups to Target: Week 4
Cardinals WR Marvin Harrison Jr. vs Commanders CB Mike Sainristil
A key matchup to exploit this week will be between rookie wide receiver Marvin Harrison Jr. and rookie cornerback Mike Sanders of the Commanders. Sanders has underperformed so far, allowing 11 receptions on 8 targets for an average of 11.5 yards per catch and a passer rating near 150.
After struggling against Ja’Marr Chase last week, Sanders will now face Marvin Harrison Jr., who has quickly become Kyler Murray's favorite target. Harrison leads the NFL with 3 receiving touchdowns this season, and he should run circles around this secondary.
Look for the Cardinals to show who is the better rookie when they have the ball.
PrizePicks to Consider: Marvin Harrison Jr. 0.5 Rush+Rec TD Scorer (Demon)
Raiders WR Davante Adams vs Browns CB Martin Emerson Jr.
Editor update: Davante Adams has been ruled out for Week 4. While TE Brock Bowers should benefit in target volume, it will be Jakobi Meyers and two 5-foot-9 receivers in Tre Tucker and DJ Turner — a third-year journey man with 0 career catches — soaking up the snaps. Meyers is the only receiver you can trust to pick up any kind of production here.
After a tough outing last week, Raiders WR Davante Adams has a prime opportunity for a bounce-back performance against Browns corner Martin Emerson Jr..
Emerson ranks 100th out of 102 corners in coverage, which bodes well for Adams, the clear No. 1 option for the Las Vegas Raiders.
Adams is top 10 in both targets and receptions in the NFL this season and has been highly effective, giving quarterback Gardner Minshew a near-perfect 100 passer rating when targeted. Adams also averages 11.6 yards per reception.
Playing at home, Adams is in an ideal position to get back on track this week.
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Best Touchdown Scorer Targets on PrizePicks: Week 4
Vikings RB Aaron Jones
Vikings RB Aaron Jones faces off against his former team, the Packers, in a revenge game.
Jones has already become a versatile weapon for the Vikings, excelling both as a rusher and receiver. The Packers' linebacker group is among the league's worst, with Isaiah McDuffie ranking 64th out of 77 graded linebackers and Quay Walker ranking 75th out of 77.
Both linebackers have struggled particularly in coverage. Jones enters the game averaging 5.4 yards per carry and has seen 14 targets through the air, making him a significant threat in this matchup in both aspects of the game.
PrizePicks to Consider: Aaron Jones 0.5 Rec+Rush TDs — MORE (Demon Pick)
Buccaneers WR Chris Godwin
Eagles CB Avonte Maddox has struggled this season, ranking 73rd out of 102 slot corners in the NFL. Unfortunately for Maddox, he faces one of the league's premier slot receivers in Bucs WR Chris Godwin.
Godwin ranks third out of 107 wide receivers in receiving grade through the first three games of the season. He’s tied for the league lead with three receiving touchdowns, ranks third in receptions with 21, and is seventh in receiving yards with 253.
When targeted, Godwin gives quarterback Baker Mayfield an impressive 150 passer rating, making this a daunting matchup for Maddox.
Expect the Buccaneers to exploit this weakness in the Eagles’ defense and for Godwin to find the end zone in a soft matchup.
PrizePicks to Consider: Chris Godwin 0.5 Rec+Rush TDs — MORE (Demon Pick)
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Lock in for Week 4 NFL DFS on PrizePicks
As Week 4 of the NFL season kicks off, we hope the PrizePicks Cheat Sheet helps you build your winning lineups this week. The Week 4 slate of games are stacked with exciting matchups, and there’s no better way to get in on the action than with PrizePicks!
Just pick two or more player projections, submit your lineup, and stay in the green during the Sunday Week 4 games to win a real money payout when the games are over.
Don’t forget to lock in your picks with the Caleb Williams free square and get ready for another Sunday sweat.
Follow Shayne Trail on X: @ShayneTrail
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