Week 11 NFL DFS Picks, Predictions & Top Matchups For Main Slate
NFL Week 11 brings us plenty of exciting matchups and DFS opportunities despite a few teams on bye. All eyes will be on the Chiefs vs. Bills, plus a huge divisional matchup between the Ravens and Steelers.
Get the most out of your Sunday experience with NFL action on PrizePicks. Below, we’ll explore the top picks for NFL DFS, injury updates for fantasy football, and defensive matchups to target to build your winning Lineup.
NFL Week 11 Picks for DFS & PrizePicks
- NFL Week 11 Injury Report for Fantasy Football
- Week 11 Pass Defenses to Target
- Week 11 Run Defenses to Target
- Week 11 DFS Picks
Week 11 NFL Injury Report for Fantasy Football
Here are injuries for NFL Week 11 that will have an impact on NFL DFS and fantasy football.
49ers TE George Kittle Managing Hamstring Injury
49ers TE George Kittle has been a regular on the injury report this season, but he has only missed one game. He is currently dealing with a hamstring injury, but there has been no indication yet that he is in danger of sitting out Sunday against the Seahawks. Kittle has racked up 7 touchdowns over his last seven games. If Kittle is out, WR Jauan Jennings should get even more involved in the passing game.
Seahawks WR DK Metcalf Trending Towards Return
Seahawks WR DK Metcalf (knee) missed two games before the Seahawks had their bye in Week 10. He is expected to return to practice Wednesday, and the team is optimistic he will take the field Sunday against the 49ers. His return could hurt Seahawks WR Jaxon Smith-Njigba, who had 13 receptions for 249 yards and two touchdowns with Metcalf sidelined.
Bills WR Amari Cooper Still Battling Wrist Injury
The Bills traded for WR Amari Cooper to provide a boost to their passing attack, but he has missed two straight games with his wrist injury. He will be limited on Wednesday. Bills WR Keon Coleman is also dealing with a wrist injury and has already been ruled out for Week 11. To complicate matters, Bills TE Dalton Kincaid is dealing with a knee injury and looks to be at least questionable for this week. Bills WR Khalil Shakir, who has 26 targets over the last three games, could once again be in line for a heavy workload.
Jaguars QB Trevor Lawrence (Shoulder) Out Again
Jaguars QB Trevor Lawrence (shoulder) did not play last week against the Vikings, and he will be out again this week. Jaguars QB Mac Jones will start again. Jones was bad in his last start, throwing for 111 yards, two interceptions, and no touchdowns. Complicating matters for the Jaguars is that RB Tank Bigsby suffered an ankle injury that could also sideline him for Week 11. If he can’t play, Jaguars RB Travis Etienne should be busy.
Other NFL Week 11 Injuries for DFS
- Lions TE Sam LaPorta is day-to-day with a shoulder injury, putting his status up in the air for a Week 11 matchup with the Jaguars. LaPorta hasn’t been racking up a ton of receiving yards, but he did catch a touchdown pass in three of his last five games. Behind him is TE Brock Wright, who only has nine receptions this season. His absence would likely just open up more downfield targets for WR Jameson Williams.
- Vikings RB Aaron Jones may be limited in practice this week because of a hamstring injury, but Vikings head coach Kevin O’Connell said that he believes that Jones will be able to play against the Titans.
- Colts WR Michael Pittman Jr. (back) missed his first game of the season last week against the Bills. Colts WR Alec Pierce caught four of seven targets for 81 yards and a touchdown in his absence and would likely be in line for added targets again if Pittman sits against the Jets. It’s hard to know what to expect with the Colts passing game week over week, but they are turning back to QB Anthony Richardson to start again.
- Steelers RB Najee Harris is dealing with an ankle injury that could limit him in practice this week. However, head coach Mike Tomlin expects Harris to play against the Ravens. The Steelers have relied on him to carry the load out of the backfield, giving him at least 19 rushing attempts in each of their last three games.
- Chiefs RB Isaiah Pacheco (leg) was designated to return from IR, but he is unlikely to play in Week 11; Kareem Hunt should continue to lead the backfield. However, WR JuJu Smith-Schuster is likely to play vs. the Bills this week. However, he should have a reduced role with WR DeAndre Hopkins in the fold.
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NFL Week 11 Pass Defenses to Target
Falcons Defense vs. Broncos
Even with the Saints missing most of their top wide receivers, Saints QB Derek Carr threw for 269 yards and two touchdowns against the Falcons last week. Saints WR Marquez Valdes-Scantling caught just three passes, but had 109 receiving yards and two touchdowns.
That has been a problem for the Falcons for much of the season, considering that they have the seventh-highest pass EPA per play allowed (0.07) in the league, per 4for4 Fantasy Football.
Looking to exploit that this week will be Broncos QB Bo Nix, who has averaged 255 passing yards per game at home, and WR Courtland Sutton, who is averaging 10 targets per game across his last three games.
PrizePicks to consider: Bo Nix 211.5 Pass Yards / Courtland Sutton 55.5 Receiving Yards
Rams Defense vs. Patriots
The Patriots might not have a great group of wide receivers, but at least their offense has some upside since they turned to QB Drake Maye as their starter. Maye has played four full games as a starter and thrown for at least 206 yards in three of them.
Up next is a favorable matchup versus the Rams, who have allowed the fourth-highest explosive pass percentage (16.01%) in the league, per 4for4.
PrizePicks to consider: Drake Maye 202.5 Pass Yards / Hunter Henry 35.5 Receiving Yards
NFL Week 11 Run Defenses to Target
Bills Defense vs. Chiefs
The Bills have struggled to stop the run, allowing the second-highest explosive rush percentage (13.83%) in the league, per 4for4. They gave up 114 rushing yards to Colts RB Jonathan Taylor last week and 119 combined rushing yards to Dolphins RB De’Von Achane and Dolphins RB Raheem Mostert the week prior.
The Chiefs have been relying heavily on RB Kareem Hunt, who has received at least 21 carries in four of his last five games.
PrizePicks to consider: Kareem Hunt 61.5 Rush Yards
Jets Defense vs. Colts
Not much has gone right for the Jets this season. Their defense was supposed to be one of the strengths of their team, but they have the seventh-highest rush EPA per play allowed (0.04) in the league. Their struggles in that department leave a ton of upside for Colts RB Jonathan Taylor, who has recorded at least 20 carries and 88 rushing yards in four of his last five games.
PrizePicks to consider: Jonathan Taylor 80.5 Rush Yards
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Week 11 NFL DFS Picks
Here are three picks to use in your NFL DFS Lineups on PrizePicks in Week 11.
Steelers WR George Pickens vs. Ravens: 66.5 Rec Yards — More
Steelers WR George Pickens has thrived since Steelers QB Russell Wilson has taken over. Pickens has 2 TDs over his last three games after failing to record a touchdown in each of his first six games. He has also recorded at least 74 receiving yards in each of the last three games.
Another hefty yardage total could be coming his way against the Ravens, who have allowed the most receiving yards to wide receivers (1,992) in the league.
Browns WR Cedric Tillman vs. Saints: 57.5 Rec Yards — More
Browns WR Cedric Tillman has taken on the leading WR role since Cooper was traded to the Bills. He was targeted at least nine times in each of the last three games. The result was him recording at least six receptions and 75 receiving yards in each game.
Expect plenty or more targets to come his way against the Saints, who have allowed the third-most receiving yards to wide receivers (1,693) in the league.
Best TD Scorer Pick: Lions WR Amon-Ra St. Brown (Demon)
Lions WR Amon-Ra St. Brown had 10 TDs across 16 games last season. He already has 7 TDs over nine games this year. He has been consistent too, posting a touchdown in each of his last seven games.
The Jaguars are tied for the eighth-most receiving touchdowns allowed to wide receivers in the league, leaving St. Brown with a favorable opportunity to continue his touchdown streak.
The Jaguars defense is also 28th in opponent’s dropback success rate (49.2%) and last in opponent’s expected points added on dropbacks.
Lions RB David Montgomery 0.5 Rush+Rec TDs — More (Goblin)
Sticking with the Lions here, RB David Montgomery hasn’t provided a ton of rushing yards. He has recorded fewer than 35 rushing yards in three of his last four games. However, he had two rushing touchdowns during that span.
He has eight touchdowns this season and 30 total rushing attempts inside the red zone. This is a great opportunity for him to score another touchdown when he faces the Jaguars, who are tied for the sixth-most rushing touchdowns allowed (11) in the league.
Note: Goblin picks reduce your payout on PrizePicks, as they are easier projections to hit.
Build Your Week 11 NFL DFS Lineup on PrizePicks
Even with four teams on a bye in Week 11, there’s still plenty of NFL action to dive into. Building your Lineup on PrizePicks for the Sunday main slate is the best way to enjoy your game day experience.
There are no salary caps to worry about, or roster restrictions; just pick two or more projections like the ones above for your favorite players, lock in your Lineup, and get ready to enjoy the Week 11 matchups.
Follow Mike Barner for more NFL DFS Picks: @rotomikebarner
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