MLB DFS Picks for PrizePicks Today: Tuesday, April 22

The Tuesday MLB slate showcases a full slate of 15 games, including several key National League matchups. The Phillies and Mets hook up in a division showdown in New York at 7:10 p.m. ET on TBS, while the Dodgers and Cubs begin a two-game series at Wrigley Field.

Welcome to today’s MLB DFS Picks, as we’ll break down Tuesday’s MLB games and give today’s best MLB DFS picks for PrizePicks for April 22, including pitcher strikeout projections, hitter projections, and a home run pick to target today.

Let’s break down some of the best MLB picks to target for the Tuesday MLB DFS slate on PrizePicks.

MLB DFS Picks on PrizePicks: Tuesday, 4/22

Here are some of the top MLB DFS picks and predictions on PrizePicks today. Use this analysis to help you build a stacked MLB Lineup on PrizePicks for Tuesday, April 22. Click each pick to read more.

• Diamondbacks P Brandon Pfaadt — 5.0 Strikeouts
• Pirates P Bailey Falter — 4.0 Strikeouts
• Twins OF Byron Buxton — 1.5 Bases
• Nationals 1B Josh Bell — 1.5 Hits+Runs+RBIs
• Home Run Pick: Braves OF Austin Riley

Diamondbacks P Brandon Pfaadt — 5.0 Strikeouts

• Diamondbacks P Brandon Pfaadt has compiled five strikeouts or less in three of four starts this season.
• The Rays have struck out less than four times in six of the last seven games against opposing starting pitchers.
• Pfaadt has a limited sample size against this Tampa Bay lineup, facing only two current batters. However, the right-hander has struck out Rays LF Christopher Morel five times in 11 at-bats.
• From a strikeouts per nine innings perspective, Pfaadt’s numbers have slipped from last season. Pfaadt posted a career-high 9.17 K/9 in 2024, but through four starts in 2025, that number has fallen to 6.85.

Pirates P Bailey Falter — 4.0 Strikeouts

• Pirates P Bailey Falter has picked up four strikeouts or more in three of four starts this season.
• The Angels have struck out at least six times against opposing starting pitchers in nine consecutive games.
• The Angels are one of three AL teams with three players that have struck out at least 25 times this season. Jorge Soler (28), Mike Trout (25), and Logan O’Hoppe (25) combined for five strikeouts in Sunday’s comeback victory over the Giants.
• Falter’s K/9 has dropped since getting dealt to Pittsburgh in 2023 from Philadelphia. The southpaw posted 7.93 strikeouts per nine innings in 2022, but that number has slipped to 6.14 this season.

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Twins OF Byron Buxton — 1.5 Total Bases

• Twins OF Byron Buxton has caught fire of late by picking up two or more hits in four of the last five games.
• Buxton rebounded from a hitless Friday night in Atlanta to compile five hits in nine at-bats in the final two games against the Braves.
• The Twins host the White Sox tonight as Chicago sends out right-hander Davis Martin. Buxton has struck out and walked in two plate appearances against Martin.
• Buxton is hitting .278 at Target Field this season, compared to a .214 average on the road. In Buxton’s last seven home games, he has racked up two bases or more five times.

Nationals 1B Josh Bell — 1.5 Hits+Runs+RBIs

• Nationals 1B Josh Bell continues to struggle at the plate this season. Bell is hitting .141 and has two hits in his last 27 at-bats. 
• Bell owns one extra-base hit in the last eight games, a home run in Friday’s 12-11 win at Colorado.
• Four of Bell’s seven runs scored this season have come at home, as the Nationals welcome in the Orioles tonight.
• Bell has not faced Orioles P Dean Kremer in his career. Kremer is sitting on a heavy 6.34 ERA in four starts, while allowing left-handed hitters to compile a .321 batting average.

Home Run Pick: Braves 3B Austin Riley

• Braves 3B Austin Riley seeks home runs in consecutive games after going deep in Monday’s victory over St. Louis.
• It marked only the second home run at Truist Park for Riley this season, compared to four homers on the road.
• Riley has seen plenty of success against Cardinals P Andre Pallante, picking up three hits in three at-bats, including a home run back in 2022.
• Pallante has allowed one home run in three of his four starts this season.
• The forecast in Atlanta calls for light wind blowing out to left field today.

Note: Demon picks increase your payout on PrizePicks, as they are harder projections to hit.

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Make MLB Picks, Win Cash on PrizePicks

There’s exciting action on Tuesday’s MLB slate as every team takes the diamond. With MLB games on tonight, now is time to build your MLB Lineup on PrizePicks.

Just pick More or Less at least two MLB player stat projections to build your Lineup on PrizePicks. Use the players above to build your Lineups around, or use a 6-Pick Lineup to reach up to 2000x payouts.

Check out the Playbook for more MLB picks all the way through the season.