MLB DFS Picks Today: Top PrizePicks Plays for Monday, 4/28

The first month of the 2025 MLB season has come and gone as some teams are still searching for their identities and trying to understand their expectations for this season. Monday’s eight-game DFS slate provides us with some key matchups that could swing anyone’s way. 

Teams will look to get a boost of momentum heading into this second month and a mid-week series is the perfect opportunity to do just that. We’ll give you the best MLB DFS picks for Monday’s MLB games, including pitchers, hitters, and a home run pick for April 28 on PrizePicks.

Highlighting Monday’s games is the St.Louis Cardinals (12-16) vs. the Cincinnati Reds (15-13) on MLB Network at 6:40 p.m. ET.

Whether you are picking Lineup filled with pitcher picks or players to get hits, there are plenty of ways to win real money on PrizePicks. Below, we’ll give you five expert picks to help you craft your MLB Lineup today.

Head to the PrizePicks MLB board, lock in your picks, and get in on real money action before the MLB games start today.

MLB DFS Picks on PrizePicks: Monday, 4/28

Here are some of the top MLB DFS picks and predictions on PrizePicks today. Use this analysis to help you build your MLB lineup on PrizePicks on Monday, April 28. Click each pick to read more.

• Astros P Ronel Blanco — 1.5 Walks Allowed (Goblin)
• Marlins P Edward Cabrera — 1.5 Earned Runs Allowed (Goblin)
• Yankees 1B Paul Goldschmidt — 1.5 Hits (Demon)
• Braves DH Marcell Ozuna — 1.5 Total Bases
• Home Run Pick: Yankees RF Aaron Judge (Demon)

Astros P Ronel Blanco — 1.5 Walks Allowed (Goblin)

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Time: 8:10 p.m. ET 

• Astros P Ronel Blanco has struggled heavily this season with control. Amongst pitchers with five starts, he ranks 12th in most walks allowed.
• Ronel Blanco has a BB% of 12%, 7.71 BB/9, and 37.9% of his 419 pitches have been balls this season.
• The Detroit Tigers rank eighth in walks so far this season (108).

Marlins P Edward Cabrera — 1.5 Earned Runs Allowed (Goblin)

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Time: 10:10 p.m. ET

• Out of his three regular season starts, Marlins P Edward Cabrera has allowed two or more runs, with an ERA of 6.14 this season.
• While Cabrera does get a lot of strikeouts, he has a 11.9 BB% and a 10% barrel rate, meaning his control can lack later in games and he could be threatened by the long ball.
• The Dodgers have scored the 9th most runs this season along with being tied for the most home runs so far this year.

Yankees 1B Paul Goldschmidt — 1.5 Hits (Demon)

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Time: 6:35 p.m. ET

• Paul Goldschmidt ranks second in MLB in hits, only behind teammate Aaron Judge.
• The Orioles are last in ERA (5.37) and second to last in hits allowed (263).
• Goldschmidt has a .365 batting average (second in MLB) along with a .417 OBP (seventh in MLB).

Braves DH Marcell Ozuna — 1.5 Total Bases

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Time: 8:40 p.m. ET

• Marcell Ozuna has the highest batting average on the Braves and 15th highest in the MLB (.316).
• Ozuna ranks better than average in every advanced hitting metric including top 6% in average exit velocity and top 33% in barrel rate percentage.
• Rockies P Ryan Feltner is giving up a 45.2% fly ball rate and 30.2% hard hit rate of opposing right-handed batters, but he’s given up only one home run in 11.1 innings.

Home Run Pick: Yankees RF Aaron Judge (Demon)

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Time: 10:10 p.m. ET

• Orioles P Tomoyuki Sugano is tied for third most home runs allowed amongst pitchers that have made five or less starts.
• The wind during the game will be blowing 5-7 mph towards the outfield and could have gusts up to 15 mph.
• Aaron Judge has the highest slugging percentage in MLB (.717) and is tied for sixth-most home runs this season.
• Sugano has surrendered a 11.2% barrel rate along with 39.8% hard hit rate this season.

Make MLB DFS Picks on PrizePicks

Monday brings us new series starting across MLB. As we near the end of the first full month of baseball, there’s no better time to get in on the real money action on PrizePicks.

Just build your MLB Lineup on PrizePicks with your favorite MLB players and win real money if your picks are correct. All you have to do is pick More or Less on at least two player projections — like hits or pitcher strikeouts — to win.

Stay locked in on the Playbook all season long for MLB player picks every day.