MLB DFS Picks, Advice for PrizePicks Tonight – 4/23/25

All 30 MLB teams are scheduled to be in action Wednesday. There are some day games on the slate, but we’ll focus on the evening set of games. There are some great matchups among them, including the Cubs hosting the Dodgers.

Below, we’ll give you the top MLB DFS picks tonight, including pitchers, hitters, and a home run pick for tonight on PrizePicks MLB.

Whether you want to attack home runs, hits, or pitcher strikeouts, the Wednesday MLB slate is loaded with opportunities on PrizePicks. Let’s highlight some picks to help you build your MLB Lineups for Wednesday’s MLB action.

Be sure to head to the PrizePicks MLB board, lock in your picks, and submit your lineup to get in on the real money MLB action before the first pitch.

MLB DFS Picks on PrizePicks: Wednesday, 4/23

Here are some of the top MLB DFS picks and predictions on PrizePicks today. Use this analysis to help you build a stacked MLB DFS Lineup on PrizePicks for Wednesday, April 23. Click each pick to read more.

• Mariners P Emerson Hancock – 5.5 Hits Allowed
• Twins P David Festa – 5.5 Strikeouts
• Dodgers OF Tommy Edman – 1.5 Hits + Runs + RBI
• Twins OF Trevor Larnach – 1.5 Hits + Runs + RBI
• Home Run Pick: Red Sox OF Wilyer Abreu

Mariners P Emerson Hancock – 5.5 Hits Allowed

• Mariners P Emerson Hancock has allowed 12 hits over 5.2 innings this season.
• Last season, Hancock allowed 62 hits over 60.2 innings.
• The Red Sox have recorded the third-most hits (214) in baseball this season.
• The Red Sox have a team batting average of .270 at home, compared to .229 on the road.

Twins P David Festa – 5.5 Strikeouts

• Twins P David Festa posted a 27.8% strikeout rate last season.
• Festa has a 26.3% strikeout rate over two starts this year.
• Festa worked his way up to 76 pitches in his last start, so he could approach 90 pitches in this outing.
• The White Sox have averaged 9.2 strikeouts per game on the road this season.

Dodgers OF Tommy Edman – 1.5 Hits+Runs RBI

• Dodgers OF Tommy Edman has recorded multiple hits in three of his last six games.
• Starting for the Cubs will be P Matthew Boyd, who has a 2.01 ERA this season. However, his 4.53 xFIP indicates that he is overperforming expectations.
• Boyd has a career 4.58 xFIP and 1.31 WHIP.
• Edman has a career .352 wOBA and .229 ISO against left-handed pitchers.

Twins OF Trevor Larnach – 1.5 Hits+Runs+RBI

• White Sox P Bryse Wilson, who has pitched mostly in relief since the beginning of the 2023 season, is expected to start this game.
• Wilson has a 1.37 WHIP for his career.
• Wilson has thrown 25 or fewer pitches in eight of his nine appearances this season, so the White Sox will likely have to go to their bullpen early. Their bullpen has a 1.35 WHIP this season.
• Twins OF Trevor Larnach has a .342 wOBA and a .172 ISO for his career at home, compared to a .289 wOBA and a .152 ISO on the road.

Home Run Pick: Red Sox OF Wilyer Abreu

• Emerson Hancock allowed 1.8 HR/9 last season. He allowed 2.0 HR/9 on the road.
• Hencock has given up a home run in both of his starts this season.
• Red Sox OF Wilyer Abreu has hit all four of his home runs this season against right-handed pitchers.
• Last season, Abreu hit 14 of his 15 home runs off righties.
• Abreu has a career .225 ISO against right-handed pitchers.

Make MLB Picks, Win Cash on PrizePicks

Wednesday’s slate should be a fun one in the MLB. After several day games to get us started, the evening is also loaded with intriguing matchups. There could also be plenty of runs scored with some underwhelming pitchers set to take the mound.

A packed MLB schedule Wednesday makes for plenty of options to win cash on PrizePicks. Now is the time to build your MLB Lineup. Just pick More or Less for at least two MLB player stat projections to build your Lineup on PrizePicks and win real money if your picks are correct. 

Check out the Playbook for more daily MLB picks throughout the season.