2025 NFL Wild Card Weekend NFL DFS Picks, Predictions & Matchups

The NFL regular season is in the books, and the NFL Playoffs are here — kicking off with Wild Card Weekend. Now it’s time to begin the path to crowning a Super Bowl champion. Wild Card Weekend gets underway Saturday, and we’ll have six games to watch over the first weekend of the NFL Playoffs.

Below, we'll get into the top NFL DFS picks, predictions, and every matchup for NFL Wild Card Weekend to help your build your Lineups on PrizePicks.

Let’s dig into some NFL DFS picks for Wild Card Weekend by highlighting some of the top projections to target on PrizePicks.

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NFL Wild Card Weekend Picks for DFS & PrizePicks

• NFL Wild Card Weekend Matchups
• NFL Wild Card Weekend DFS Picks
• Chargers QB Justin Herbert 1.5 Pass TDs — More
• Buccaneers WR Jalen McMillan 51.5 Receiving Yards — More
• Best TD Scorer Pick: Ravens TE Mark Andrews (Demon Pick)
• Goblin Pick: Buccaneers RB Bucky Irving 0.5 Rush+Rec TDs — More

NFL Wild Card Weekend Matchups

Here are the NFL Wild Card Weekend matchups and schedule. You can find the full NFL Playoffs Bracket and predictions here.  

Los Angeles Chargers at Houston Texans: January 11, 4:30 p.m. ET

• The Chargers had a 6-3 record on the road during the regular season.
• The Chargers allowed the fewest points per game (17.7) in the league.
• After missing four weeks with an ankle injury. Chargers RB J.K. Dobbins returned to log at least 18 carries in both of the final two games of the season.
• The Texans had a 0 point differential, despite going 10-7.
• The Texans lost three of their final five games.
• Texans QB CJ Stroud was sacked 52 times (second-most in the NFL). The Chargers ranked sixth in sacks with 46.

Pittsburgh Steelers at Baltimore Ravens: January 11, 8 p.m. ET

• Ravens went 6-2 at home this season, while the Steelers went 5-4 on the road.
• The Steelers finished the season on a four-game losing streak, and have not scored over 17 points in any of those games.
• Teams split the regular season series. The Ravens won in Baltimore, and the Steelers won in Pittsburgh.
• The Steelers scored less than 20 points in both games against the Steelers this year.
• Ravens WR Zay Flowers (knee) is viewed as a “longshot” to play.
• Ravens TE Mark Andrews has scored in six-straight games.

Denver Broncos at Buffalo Bills: January 12, 1 p.m. ET

• Bills went 8-0 at home this season, while the Broncos had a 4-5 record on the road. The Bills have the best home record in the NFL since 2020.
• Bills averaged the second-most points per game (30.9) during the regular season.
• The Broncos had only two wins against NFL Playoff teams this year, against the Bucs in Week 3, and the second-string Chiefs in Week 18.
• Bo Nix had more passing yards than Josh Allen this season, although Allen sat out for most of the Bills’ meaningless Week 18 game.

Green Bay Packers at Philadelphia Eagles: January 12, 4:30 p.m. ET

• Eagles QB Jalen Hurts is still in the concussion protocol after missing the last two weeks of the regular season.
• Packers WR Christian Watson will not play after suffering a torn ACL in Week 18 versus the Bears.
• Packers QB Jordan Love (hand) expected to play, but may be limited in practice.
• Packers tied for the third-most interceptions (17) in the league during the regular season.

Washington Commanders at Tampa Bay Buccaneers: January 12, 8 p.m. ET

• Commanders QB Jayden Daniels is expected to be fine after leaving Week 18 against the Cowboys with leg soreness.
• Buccaneers QB Baker Mayfield was tied for the second-most touchdown passes in the league (41) this season. He also had the third-most passing yards (4,500).
• Buccaneers tied for the sixth-most sacks (46) in the league.

Minnesota Vikings at Los Angeles Rams: January 13, 8 p.m. ET

• The Rams won the first matchup between these two teams in Los Angeles, 30-20.
• Both QBs threw for 240+ yards in that game, while WRs Puka Nacua and Justin Jefferson both went over 100 yards receiving.
• The Vikings were 6-2 on the road this season, while the Rams were 5-4 at home.
• Rams RB Blake Corum fractured his forearm and will miss the Playoffs
• In games where Corum had zero carries this year, RB Kyren Williams averaged 20.3 carries per game.

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Wild Card Weekend NFL DFS Picks

Here are the top NFL DFS picks for Wild Card Weekend on PrizePicks.

Chargers QB Justin Herbert 1.5 Pass TDs – More

Chargers QB Justin Herbert threw at least two touchdown passes in each of his final four games during the regular season. The Texans allowed the third-most passing touchdowns (31) in the league during the regular season. Part of that can be attributed to them being tied for the fourth-fewest rushing touchdowns allowed (11). Look for Herbert to continue his streak of consecutive games with multiple touchdown passes.

Buccaneers WR Jalen McMillan 51.5 Receiving Yards – More

Buccaneers WR Mike Evans gets all of the headlines, but Buccaneers WR Jalen McMillan has also become an important part of the team. He finished the regular season by posting at least 51 receiving yards in each of his final five games. Working in his favor has been his average depth of target being 11.9 yards. With the Commanders likely focusing efforts on trying to slow down Evans, McMillan has the potential for another productive performance.

Best Touchdown Scorer Pick: Ravens TE Mark Andrews (Demon)

Ravens TE Mark Andrews set a new career high with 11 touchdown receptions during the regular season. That included him recording a touchdown pass in each of his final six games. During that streak, he caught a touchdown against the Steelers in Week 16. The Steelers gave up seven touchdowns to tight ends this season, leaving Andrews with a favorable opportunity to reach the end zone again.

Note: Demon picks add a payout boost to your lineup on PrizePicks, as they are more difficult projections to hit.

Goblin Pick: Buccaneers RB Bucky Irving 0.5 Rush+Rec TDs – More

When the Buccaneers get near the end zone, they like to give the ball to RB Bucky Irving. He has received at least two carries inside the red zone in seven of his last eight games. During that span, he scored five touchdowns. The Commanders allowed 16 rushing touchdowns this season, which is the most of any playoff team. Expect them to have a difficult time keeping Irving out of the end zone.

Note: Goblin picks reduce your payout on PrizePicks, as they are easier projections to hit.

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Build Your Wild Card Weekend NFL DFS Lineup on PrizePicks

The NFL playoffs bring another level of excitement to the NFL and NFL DFS. There is no better way to get in on the real money action than by building an NFL team on PrizePicks for Wild Card Weekend.

There are no salary constraints, so pick two or more projections for your favorite players, finalize your lineup, sit back, and enjoy the games. If your picks are right, you’ll get paid instantly!