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MLB DFS Picks Today: Top Plays for Friday, 4/4

April 4, 2025

April 4, 2025

Pirates P Mitch Keller is a top MLB DFS pick for PrizePicks today in the Pirates vs. Yankees game.

Sam Hodde/Getty Images

A jam-packed Friday MLB slate with 14 games to pick from as teams begin their weekend series. We’ve got today’s top MLB DFS picks for MLB today, including pitchers and hitters to target on PrizePicks for today’s slate, plus a home run pick.

Whether you’re backing pitchers' strikeouts or a hitter’s home run square, Friday's MLB slate is stacked with opportunities on PrizePicks. Below, we’ve got five picks to help you build your Lineups.

Don’t forget to head to the PrizePicks MLB board, lock in your picks, and submit your lineup to get in on the real money MLB action before the first pitch.

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MLB DFS Picks on PrizePicks: Friday, 4/4

Here are the top MLB DFS picks and predictions for PrizePicks today. Use this analysis to build your Lineups on PrizePicks MLB on Friday April 4. Click to read more about each pick.

Pirates P Mitch Keller — 5.5 Strikeouts

MLB DFS Picks Today - Mitch Keller

Time: 4:12 p.m. ET

Pirates P Mitch Keller is set to face the red-hot New York Yankees, but the Yankees have an Achilles’ heel — their occasional inability to make consistent contact, leading to higher strikeouts than league average. 

Over 105+ plate appearances, the Yankees posted a 34% strikeout rate, and among their projected hitters today, four have exceeded a 38% strikeout rate early in the season. Dating back to last season, Keller has recorded six or more strikeouts in four of his last six starts.

Keller had a solid 24% K rate against lefties last season — compared to 18.8% vs. right-handed bats, and is projected to face six left-handed Yankees hitters today, highlighting a significant vulnerability for New York.

Nationals P Jake Irvin — 1.5 Earned Runs Allowed (Goblin)

MLB DFS Picks Today - Jake Irvin

Time: 6:45 p.m. ET

Nationals P Jake Irvin emerged as one of the bottom-tier pitchers in MLB last season. Over 700 plate appearances, he posted a 9.5% barrel rate, a 46% hard-hit percentage, and a very low 9% swinging strike percentage. In stark contrast, the Diamondbacks are off to a hot start this season; players with 30+ plate appearances are posting a BABIP above .500, an encouraging sign for the Diamondbacks' offensive potential in this matchup.

Note: Goblin picks reduce your payout on PrizePicks, as they are easier projections to hit.

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Braves DH Marcell Ozuna — 1.5 Total Bases (Demon)

MLB DFS Picks Today - Marcell Ozuna

Time: 7:15 p.m. ET

Marlins P Max Meyer had an unforgettable season last year. In 250 plate appearances, he allowed a 14% barrel rate and generated a 56% contact rate, but his slider emerged as a significant liability — yielding a mere 10% swinging strike percentage.

Braves DH Marcell Ozuna excelled against right-handed sliders. Over 85 plate appearances, he smashed the pitch for a 60% hard-hit percentage, a 22% barrel rate, and a 30% flyball rate making Ozuna one of Meyers toughest matchups today. 

Orioles 1B Ryan Mountcastle — 1.5 Hits+Runs+RBIs

MLB DFS Picks Today - Ryan Mountcastle

Time: 7:40 p.m. ET
Royals P Seth Lugo struggled against right-handed hitters last season. In over 400 plate appearances, his right-handed fastball yielded an 11% barrel rate, a 43% hard-hit percentage, and nearly a 30% fly-ball rate. On the other side, Orioles 1B Ryan Mountcastle recorded a 19% barrel rate, a 67% hard-hit percentage, and an impressive 34% fly-ball rate in 80+ plate appearances against the same pitch. This stark contrast makes Mountcastle a key offensive threat against Lugo, exposing the weaknesses in Lugo’s fastball.

Home Run Pick: Dodgers DH Teoscar Hernandez (Demon)

MLB DFS Picks Today - Teoscar Hernandez

Time: 6:45 p.m. ET
Phillies P Jesus Luzardo is slated to take on the powerhouse Los Angeles Dodgers. Unfortunately for Luzardo, he is especially susceptible to the long ball. Last season, his left-handed fastball produced a 10% barrel rate, 50% hard-hit percentage, and 32% fly-ball rate against right-handed hitters.

In contrast, Teoscar Hernandez, facing the same pitch type in over 40 plate appearances, posted a 30% fly-ball rate, a 50% hard-hit percentage, and a 20% barrel rate. With Luzardo’s fastball being his most frequently thrown pitch, this tendency makes him particularly vulnerable to the long ball against Dodgers' right-handed hitters.

Note: Demon picks increase your payout on PrizePicks, as they are harder projections to hit.

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Cash in on MLB DFS on PrizePicks

You’ve got the MLB picks for Friday’s MLB slate. Aces will take the mound in an exciting slate of action as new series get underway today. Now it’s time to build your MLB lineup on PrizePicks

All you have to do is pick More or Less on at least two player projections — like hits or strikeouts — to win real money on the PrizePicks MLB action.

Whether you’re going with demons or goblins, there’s always real money sports action waiting for you on PrizePicks. Stay locked in on the Playbook all season long for MLB player picks every day.

Follow Shayne Trail for more MLB Picks: @ShayneTrail

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